Effect of Chronic Benzalkonium Chloride Exposure on Senescence in Trabecular Meshwork Cells
نویسندگان
چکیده
منابع مشابه
Effects of benzalkonium chloride- or polyquad-preserved fixed combination glaucoma medications on human trabecular meshwork cells
PURPOSE We investigated the potential short and long-term effects in cultured human trabecular meshwork (TM) cells of various topical glaucoma formulations containing different preservatives. METHODS We tested the fixed combination medications 0.004% travoprost plus 0.5% timolol preserved with either 0.015% benzalkonium chloride (BAK; DuoTrav®), or with 0.001% polyquad (PQ; DuoTrav(®) BAK-fre...
متن کاملEffect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells
PURPOSE The objectives of this study were to evaluate the potential release of ATP that is mediated by mechanical stress on trabecular meshwork (TM) cells, to identify the specific P2Y receptors mediating the ATP response, and to determine whether cellular senescence might interfere with the P2Y receptor-mediated calcium response, thus contributing to the loss of physiologic TM function in agin...
متن کاملEffect of Advanced Glycation End Products on Oxidative Stress and Senescence of Trabecular Meshwork Cells
PURPOSE To investigate the effect of advanced glycation end products (AGE) on oxidative stress and cellular senescence in cultured human trabecular meshwork cells (HTMC). METHODS Primarily cultured HTMC were exposed to 0, 10, 50, 100, 200 µg/mL of glycated bovine serum albumin (G-BSA) for 5 days. Also co-exposed were L-arginine, sepiapterin, and antioxidant N-acetylcysteine (NAC). Cellular su...
متن کاملIn vitro and in vivo experimental studies on trabecular meshwork degeneration induced by benzalkonium chloride (an American Ophthalmological Society thesis).
PURPOSE Long-term antiglaucomatous drug administration may cause irritation, dry eye, allergy, subconjunctival fibrosis, or increased risk of glaucoma surgery failure, potentially due to the preservative benzalkonium chloride (BAK), whose toxic, proinflammatory, and detergent effects have extensively been shown experimentally. We hypothesize that BAK also influences trabecular meshwork (TM) deg...
متن کاملEffect of H-7 on cultured human trabecular meshwork cells.
PURPOSE To determine the effect of the serine-threonine kinase inhibitor H-7, which blocks actomyosin contractility and increases outflow facility in live monkeys, on morphology, cytoskeleton, and cellular adhesions of human trabecular meshwork (HTM) cells in culture. METHODS Cultured HTM cells were videographically recorded and evaluated before and after exposure to H-7 at different concentr...
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ژورنال
عنوان ژورنال: Journal of the Korean Ophthalmological Society
سال: 2019
ISSN: 0378-6471,2092-9374
DOI: 10.3341/jkos.2019.60.1.55